姓名：字成庭

职称：教授

导师：博士生导师

专业：化学

邮箱：zichengting@126.com

n 教育和工作简历

u 2020.10-至今，云南农业大学，教授，化学系

u 2018.01-2020.9，云南农业大学，副教授，化学系

u 2015.08-2017.12，云南农业大学，博士见习

n 学术兼职

u 中国化学学会会员

u 云南省微生物协会会员

u 食品安全风险评估委员

n 教学工作

u 研究生课程：食品营养学研究进展、细胞及分子生物学实验技术、现代食品营养学

u 本科生课程：有机化学、有机化学I、有机化学II、应化Seminar、有机化学实验、应用高分子化学、仪器分析实验、普通化学、普通化学实验

n 研究方向

u 农业化学基础研究及应用

u 食药同源化学物质基础及生物学功效

u 天然多糖化学生物学及其应用基础研究

n 管理服务工作

u 副院长

n 奖励与荣誉

u 云南省“兴滇英才”计划青年人才（2020年）

n 研究项目

u 国家自然科学地区基金项目“新型铁皮石斛素类微管蛋白抑制剂的挖掘及作用机理研究”（编号：31960075）, 2020.01–2023.12, 项目负责人

u 国家自然科学基金青年项目“表没食子儿茶素没食子酸酯（EGCG）氧化物的选择性合成、分离及抗肿瘤活性研究”（编号：21602196），2017.01–2019.12，项目负责人

u 云南省农业联合专项重点项目“茶多酚纳米聚集体功能化TKIs的构建及其在靶向治疗非小细胞肺癌的应用研究”（编号：202101BD070001-028），2022.01–2024.12，项目负责人

u 云南省农业联合专项面上项目“儿茶素类化合物的化学修饰对其生物利用度屏障的作用及机理研究”（编号：2017FG001（-046）），2017.09–2020.08，项目负责人

u 云南省自然科学基金青年项目“化学选择性EGCG偶联氧化产物的合成及抗肿瘤活性研究”（ 编号：2017FD084），2017.06–2020.05，项目负责人

n 代表性论文

u Yan-Ping Huang^#, Xiang-Dan Cuan^#, Wei-wei Zhu, Xing-Ying Yang, Yun-Li Zhao, Jun Sheng, Cheng-Ting Zi^*, Xuan-Jun Wang^*. An EGCG Derivative in Combination with Nimotuzumab for the Treatment of Wild-Type EGFR NSCLC. Int. J. Mol. Sci. 2023, 24 (18), 14012.

u Jia-Min Xian^#, Hong-Tao Hu^#, Shu Yang^#, Yu-Na Wang, Zhuo-Yi Wang, Ruo-Han Zhang, Cheng-Ting Zi^*, Pei-Yuan Sun^*, Jing Wang^*. Inhibitory Effect of Magnolol on Activation of EGFR L858R/T790M/G796R. BJSTR., 2023, 50 (3), 41660-41666.

u Liu Yang^#, ChengTing Zi^#, Ding-Kang Chen, Jin-Yu Li, Rui He, Jiang-Miao Hu^*. Target acquisition of anti-aging manno-oligosaccharide that triggers ECM process via TGF-β/Smads-SIRT1 signalling pathway. Carbohyd. Polym. 2022, 22, 120380.

u Cheng-Ting Zi^#, Yin-Rong Xie^#, Yun Niu^#, Zhen-Hao Liu, Liu Yang, Yong-Kai Xi, Zhen-Jie Li, Feng-Mei Zhang, Ze-Min Xiang^*, Jun Sheng^*. Novel cannabidiol (CBD) derivatives: Synthesis, anti-inflammatory activity, and molecular docking. Phytochem. Lett. 2022, 51, 97–103.

u Xiu-Li Sun^#, Ze-Min Xiang^#, Yin-Rong Xie^#, Ning Zhang, Li-Xia Wang, Yi-Long Wu, Dong-Ying Zhang, Xuan-Jun Wang^*, Jun Sheng^*, Cheng-Ting Zi^*. Dimeric-(-)-eigallocatechin-3-gallate inhibits the proliferation of lung cancer cells by inhibiting the EGFR signaling pathway. Chem-Biol. Interact. 2022, 365, 110084.

u Yan-Ping Huang^#, Xiang-Dan Cuan^#, Xing-Ying Yang, Wei-Wei Zhu, Yun-Li Zhao, Li Jiang, Cheng-Ting Zi^*, Xuan-Jun Wang^*, Jun Sheng^*. Oxidized tea polyphenol (OTP-3) targets EGFR synergistic nimotuzumab at inhibition of non-small cell lung tumor growth. Bioorg. Chem. 2022, 128, 106084.

u Si-Si Chen^#, Liu Yang^#, Xia Qu^#, Jin-Yu Li^#, Cheng-Ting Zi, Hao Wang^*, Jiang-Miao Hu^*, Ye Liu^*. A new polysaccharide platform constructs self-adjuvant nanovaccines to enhance immune responses. J. Nanobiotechnol. 2022, 20, 320.

u Ye-Wei Huang^#, Jing-Yun Yan^#, Xiu-Li Sun^#, Yun Niu, Wen-Jun Yuan, Ling-Bin Kong, Xiang-Dong Qin, Cheng-Ting Zi^*, Xuan-Jun Wang^*, Jun Sheng^*. Anticancer effects of dendrocandin (DDCD) against AKT in Hpeg2 cells using Molecular Modeling, DFT and in Vitro Study. Struct. Chem. 2022, 33, 1331–1340.

u Ning Zhang^#, Yi-Long Wu^#, Miao Qiao, Wen-Juan Yuan, Xing-Yu Li, Xuan-Jun Wang^*, Jun Sheng^*, Cheng-Ting Zi^*. Structure–antioxidant activity relationships of dendrocandin analogues determined using density functional theory. Struct. Chem. 2022, 33, 795–805.

u Li-Xia Wang^#, Ze-Hao Wang, Xiu-Li Sun, Cheng-Ting Zi*, Xuan-Jun Wang^*, Jun Sheng^*. Discovery of EGFR-Targeted Environment-Sensitive Fluorescent Probes for Cell Imaging and Efficient Tumor Detection. Bioorg. Chem. 2022. 121, 105585.Published: 2022-01-04

u Ya Wang^#, Xiao-Jing Shen^#, Fa-Wu Su^#, Yin-Rong Xie, Li-Xia Wang, Ning Zhang, Yi-Long Wu , Yun Niu, Dong-Ying Zhang, Cheng-Ting Zi^*, Xuan-Jun Wang^*, Jun Sheng. Novel per-butyrylated glucoses derivatives of (-)-epigallocatechin-3-gallate inhibit cancer cells proliferation by decreasing phosphorylation of the EGFR: Synthesis, cytotoxicity and molecular docking. Molecules. 2021, 26 (14) 4361.

u Cheng-Ting Zi^#, Ze-Hao Wang^#, Jing Shi^#, Boya Shi, Ning Zhang, Yi-Ling Wu, Yin-Rong Xie, Lu Zhou, Chun Xiao^*, Xuan-Jun Wang^*, Jun Sheng^*. Synthesis, cytotoxicity and molecular docking of methylated (-)-epigallocatechin-3-gallate-4β-triazolopodophyllotoxin derivatives as novel antitumor agents. J. Chem. Res. 2021:1–7.

u Ze-Hao Wang^#, Li-Xia Wang^#, Bo-Ya Shi, Xiu-Li Sun, Yin-Rong Xie, Hao-Nan Yang, Cheng-Ting Zi^*, Xuan-Jun Wang^*, Jun Sheng^*. Demethyleneberberine promotes apoptosis and suppresses TGF-β/Smads induced EMT in the colon cancer cells HCT-116. Cell Biochem. Fun. 2021: 1–8.

u Bo-Ya Shi^#, Ze-Hao Wang^#, Ning Zhang, Yin-Rong Xie, Xiu-Li Sun, Hao-Nan Yang, Yi-Long Wu, Cheng-Ting Zi^*, Xuan-Jun Wang^*, Jun Sheng^*. Synthesis and Anticancer Activity of Glucosylated novel (-)-Epigallocatechin-3-gallate Derivatives Linked via Triazole Rings. Med. Chem. Res. 2021, 30: 1240–1248.

u Jing-Yun Yan^#, Hao-Nan Yang^#, Ning Yang, Yin-Rong Xie, Xiu-Li Sun, Ye-Wei Huang, Cheng-Ting Zi^*, Xuan-Jun Wang^*, Jun Sheng^*. Synthesis and in vitro biological evaluation of novel dendrocandin analogue as potential anti-tumor agent. Nat. Prod. Res. 2021:1–6.

u Boya Shi, Zehao Wang, Xuanjun Wang, Jun Sheng^*, Chengting Zi^*. Recent progress of small-molecule epidermal growth factor receptor (EGFR) inhibitors. Med. Res. 20202020, 4 (200011), 1–4.

u Canpeng Li^#, Yuxun Lu^#, Chengting Zi^#, Yuting Zhao, Hui Zhao^*, Yaping Zhang^*. Cationic pillar[6]arene induces cell apoptosis by inhibiting protein tyrosine phosphorylation via host-guest recognition. Int. J. Mol. Sci. 2020, 21, 7949.

u Chengting Zi^#, Liu Yang^#, Yue Hu, Pan Zhang, Han Tang, Banglei Zhang, Xiaojing Shen, Qinghua Kong, Ya Wang^*, Xuanjun Wang^*, Jun Sheng^*. Synthesis, antitumor activity, and molecular docking of (-)-epigallocatechin-3-gallate-4β-triazolopodophyllotoxin conjugates. J. Asin Nat. Prod. Res. 2021, 23 (8), 772-780.

u Chengting Zi^#, Peiyuan Sun^#, Ning Zhang, Han Tang, Haonan Yang, Qi Wang, Yuna Wang, Jing Wang^*, Xuanjun Wang^*, Jun Sheng^*. Glucosylated (-)-Epigallocatechin-3-gallate (EGCG) derivative via triazole ring: Synthesis and combined with cisplatin/paclitaxel inhibits NSCLC cancer cells by decreasing phosphorylation of the EGFR. J. Chem. Res. 2020, 44 (9-10) 586–591.

u Yuna Wang^#, Jing Wang^#, Hao-Nan Yang, Bang-Lei Zhang, Pan Zhang, Pei-Yuan Sun, Ning Zhang, Ya Wang, Jun Sheng^*, Xuan-Jun Wang^*, Cheng-Ting Zi^*. The oxidation of (-)-epigallocatechin-3-gallate inhibits T-Cell Acute Lymphoblastic Leukemia cell line HPB-ALL via the regulation of Notch1 expression. RSC Adv. 2020, 10, 1679–1684.

n 代表性著作

u 参编《有机化学》

u 参编《普通化学与定量分析化学学习指导及习题解答》等书

n 专利及标准

u 盛军，王宣军，字成庭，王晶，向泽敏，黄业伟，王娅，吴晓云，方崇业，刘佳，张冬英，汪琦，唐晗，张帮磊，王玉娜.表没食子儿茶素没食子酸酯糖苷衍生物及其应用，专利公开号：CN201810094218.6

u 盛军，王宣军，黄艳苹，字成庭，向泽敏，黄业伟，赵云丽，爨向丹，徐欢欢，罗瑞. 表没食子儿茶素没食子酸酯糖苷衍生物及其应用，专利公开号：CN 110038006 A

u 字成庭，盛军，王宣军，燕静云，杨豪男，张帮磊，胡月，杨宁，张宁，吴以龙.铁皮石斛素类似物及其制备方法和用途.专利公开号：CN 112266377 A

u 字成庭，盛军，王宣军，张宁，杨豪男，袁文娟，乔妙，孙秀丽.一种铁皮石斛素及其制备方法.专利公开号：CN 113045536

u 盛军，字成庭，王宣军，袁文娟，孙秀丽，张帮磊，杨豪男，谢引荣，燕静云，胡月，张宁，杨宁.铁皮石斛素及其制备抗癌药物的应用.专利公开号：CN 112979608 A

u 盛军，字成庭，王宣军，袁文娟，孙秀丽，谢引荣，杨豪男，王丽霞，张宁，吴以龙，施博雅，王泽昊.铁皮石斛素及其用途.专利公开号：CN 112939928 A

u 字成庭，盛军，王宣军，张宁，吴以龙.一种用于电化学工作站检测的多功能电解池.专利号：ZL 2020 2 2833997.2申请时间：2020.12.01授权时间：2021.10.19

u字成庭，盛军，王宣军，吴以龙，张宁.一种用于分离茶多糖和聚合多酚的装置.专利号：ZL 2020 2 3008416.8

n 学生工作

u 指导已经毕业研究生5名，在读研究生5名，发表论文22篇。

u 指导本科生30名，本科生与发表科研论文8篇。